| Date | Opponent | Location | Time | Score | Links |
| Sep 3, 2005 | Winston-Salem State | Final | W, 20-6 | Box Score | |
| Sep 10, 2005 | Hampton * | Final | L, 22-12 | Box Score Recap | |
| Sep 17, 2005 | at Florida A&M University | Final | L, 33-20 | Box Score Recap | |
| Sep 24, 2005 | at Savannah State | Final | W, 39-21 | Box Score Recap | |
| Oct 1, 2005 | at Charleston Southern | Final | W, 27-22 | Box Score Recap | |
| Oct 15, 2005 | at Morgan State * | Final | L, 7-0 | Box Score Recap | |
| Oct 22, 2005 | North Carolina A&T * | Homecoming | Final | W, 16-0 | Box Score Recap |
| Oct 29, 2005 | at Norfolk State * | Final | L, 26-7 | Box Score Recap | |
| Nov 5, 2005 | South Carolina State * | Hall of Fame Weekend | Final | L, 23-9 | Box Score Recap |
| Nov 12, 2005 | Bethune Cookman * | Final | L, 45-16 | Box Score Recap | |
| Nov 19, 2005 | at Delaware State * | Final | L, 23-7 | Box Score Recap | |
| Home games in bold. * = Conference games. | |||||