Before undergoing deoxycholic acid injection, patients should be fully aware of the risks involved in this procedure. There are many precautions to be followed, including avoiding local and topical anesthesia, excessive skin laxity, and cervical lymphadenopathy. The injection should be performed only by a certified clinician. The injection should target the subcutaneous fat between the platysma and dermis. The patient should also have provided prior informed consent before treatment.
Side effects of deoxycholic acid injections
Deoxycholic acid is a 2ndry bile acid produced by intestinal bacteria. It aids in the absorption of fat by destroying adipocytes. The resulting inflammatory tissue response reduces the amount of fat in the body. Although deoxycholic acid is very effective for reducing fat, it can have negative side effects, such as bruising and pain after the injection. It can also interact with similar drugs, such as those used to prevent blood clots.
Other drugs may interfere with the absorption of deoxycholic acid. It is, therefore, crucial to check with your doctor before getting this treatment. Aluminum hydroxide, aluminum oxide, and aluminum sulfate are all known to inhibit the absorption of deoxycholic acid. If you ache from any of these conditions, your healthcare provider may prescribe an alternative treatment. It would help if you also built sure to keep all medications out of the reach of children. Also, you should always take your medication according to the instructions provided by your healthcare provider.
Patients can be treated with deoxycholic acid if the subcutaneous fat is in the submental area. Your doctor will first examine your neck to assess if you have excessive fat. In addition, your doctor may use a topical anesthetic to reduce pain during the procedure. The treatment will usually last for about an hour, and you may need up to 50 injections during each session.
Mechanism of action of deoxycholic acid
Injecting deoxycholic acid into the body causes a series of physiological changes. First, the molecule acts as a cytolytic agent, disrupting the adipocyte cell membrane. This action causes the cells to lyse and release fatty acids into the bloodstream. A tissue response follows, and macrophages attract the treated area to eliminate cellular debris and lipids. Fat cells are subsequently cleared naturally by the body. Additionally, collagen is increased, and fibroblasts appear in the area.
Endogenous deoxycholic acid levels vary among individuals. Most of this substance is sequestered in the enterohepatic circulation loop. Injecting deoxycholic acid is safe for most people, but there are some risks. Infected areas, medical conditions in the neck area, and problems swallowing are potential complications of deoxycholic acid injection. The process is also associated with side effects, including pain, infection, and bleeding.
While KYBELLA (r) does not cause toxicity in humans, animal studies have been limited. A small volume of distribution and intermittent administration of deoxycholic acid is safe. This acid also contributes to the bile acid pool in the body. It joins the bile acids that are eliminated from the body without contributing significantly to the metabolic rate. Injections of deoxycholic acid do not induce CYP1A.
Possible drug interactions with deoxycholic acid
Deoxycholic acid is a man-made version of a natural substance that destroys fat cells when injected into the body. It is most commonly wanted to treat fat below the chin but has not been studied extensively for use on other body parts. It may also interact with similar medications and treatments, so it is important to use the medicine only for the intended purpose. Make sure to follow all steps on the label and tell your healthcare provider about any existing medical conditions you have.
The amount of deoxycholic acid injected into the submental area should be adjusted to the size of the problem area. A single treatment consists of a series of injections separated by one cm, with a maximum of 50 injections required. Patients may receive up to six single sessions, each no more than a month apart. A healthcare provider should perform these injections.
The drug may increase the risk of local adverse effects. Although it does not affect the liver, it is unknown if the drug will interact with any medications. The most common side effects included headaches, nausea, and diarrhea. The dose should be increased if necessary to reduce the risks of these adverse effects. Some patients may experience skin reactions. In addition, deoxycholic acid may affect blood pressure, muscle function, and the immune system.