The science, close to getting a pain pill without adverse effects

An international team of researchers is testing a new pain pill that has fewer side effects than the usual ones. non-steroidal anti-inflammatory drugs (NSAIDs). It is an important advance in the field of pain relief treatments.

It must be taken into account that ibuprofen is part of non-steroidal anti-inflammatory drugs (NSAIDs). Therefore, according to reports from ' European Journal of Pharmaceutical Sciences ', this new pain pill has fewer side effects than ibuprofen.

Currently, non-steroidal anti-inflammatory drugs are used to treat muscle pain, headaches and other types of pain. Although, this type of medication has a series of side effects, as with any type of medication.

Looking for a safer pain pill

Non-steroidal anti-inflammatory drugs (NSAIDs) act to minimize pain and fight inflammation by inhibiting any of the enzymes (cyclooxygenase-1 or -2, also known as COX-1 / COX-2) present in abundance in the places biological factors of inflammation.

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However, one of the disadvantages of this type of medication is that it can also cause serious side effects, such as stomach ulcers, kidney malfunction or even heart failure.

For this reason, for years, science has been working in search of a pain pill with an anti-inflammatory and analgesic character, but safer for health. In this sense, a compound called AD 732 has recently been synthesized that offers promising results in this regard.

Due to the promising results of this compound, an international group of researchers led by Dr. Kikuko Amagase, from Ritsumeikan University (Japan), and Professor A. Bekhit, from the University of Alexandria (Egypt) study the therapeutic efficacy of this compound and the possible side effects in rats.

An alternative to non-steroidal anti-inflammatory drugs

Dr. Amagase explains in this regard that “in a previous study, we synthesized this compound AD 732. In this study, we compared it to two standard drugs: indomethacin, a prototype NSAID, and celecoxib, a COX-inhibitor. We wanted to evaluate its efficacy and adverse effects in relieving acute and chronic pain. ”

This group of researchers reports that the results were encouraging in relation to this pain pill . Thus, AD 732 offered better anti-inflammatory and analgesic effects than standard agents. Most importantly, they did not show ulcer effects or kidney function damage.

With all this, Dr. Bekhit argues that «the findings on the lower inhibition of COX-2 by AD 732 could indicate that this is not the only mechanism that contributes to its anti-inflammatory actions ”. Therefore, it is essential to continue investigating in depth to observe its specific mechanism of action.

Finally, as a conclusion, Dr. Amagase points out that «it can be concluded that the compound AD 732 seems be a safer and more effective molecule with promising potential for treating pain and inflammation, even in difficult diseases such as ulcerative colitis and Crohn's disease. ”

Based on these encouraging results, the main author of this research confesses that we may soon be able to kill pain without causing any harm to our body.

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