The prostate must be one of the most relevant health issues for men as we age for a multitude of reasons. We well know that the prostate is the glandular organ of the male genitourinary system, which over the years, can be damaged.
Taking care of our prostate is more than essential to avoid infections or other types of more serious diseases such as cancer .
However, if you have this type of cancer in your body, we are going to leave you with the last two proteins that have been identified for their negative effect on this pathology.
Against prostate cancer
Specifically, researchers from the Medical University of Vienna (Austria) have been able to identify these two cancer markers in patients with aggressive prostate cancer.
These are the proteins NDUFS1 and ATP50, which according to the Austrian study, reveal a lower survival and will serve in the future for new studies in which the risk of the disease will be evaluated.
Similarly, it will be about getting new formulas for the treatment in which better results can be achieved than those that are thrown today.
Published in the journal «Cancers», from a previous study created in 2016, This research recovers how a mouse was used from Vienna to demonstrate how the STAT3 protein has a suppressive role of tumors in said cancer.
After said publication, evidence was also left that patients who had low levels of STAT3 in cancer cells had a more severe worsening than others with high levels.
The cancer tissue had a higher metabolic rate at that time, so the tumor had a plus to be able to grow and make your metastasis.
Study of proteins
In the new study, prostate cancer tissue was separated and the proteome was taken into account, the analysis of proteins present.
There, the large number of peptides and proteins of different types and sizes was verified, thanks to the use of a laser microscope.
And then the researchers realized how there was a higher concentration of respiratory chain proteins mitochondrial in the most aggressive tissue.
For those who don't know, mitochondria are those organs that form enzymatic complexes, where degradation occurs in the decomposition of sugars.
Regulates, therefore, the cellular processes in the production of energy in our body, essential for the functioning of the organism.
It was concluded that the proteins NDUFS1 and ATP50 were related to a lower probability of survival in situations very complicated cases of prostate cancer.
Thus, the two proteins serve as immunohistochemical markers for aggressive prostate tumors, and to be able to continue research along the same lines.